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Research on I3C dates to the 1960s when it was investigated for its actions against chemical carcinogens. Since that time, researchers have been able to show that I3C has powerful and diverse ways of stopping cancer. While the break-down products of I3C may act unpredictably by themselves, when taken as I3C they are beneficial for preventing, and possibly treating, hormone-related cancers. The data is so compelling, it has provoked normally reserved researchers into such praise as, ³I3C has tremendous potential in the treatment and prevention of cancer, particularly estrogen-enhanced cancer.² (Meng Q, et al. 2000. J Nutr 130:2927-31)