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PHOSPHATIDYLSERINE(PS) is an endogenously produced phos- pholipid that is embedded in cell membranes and is the major phos- pholipids in the brain. Its general functions include supporting cellular chemical signal transmissions, activating cell surface receptors. and cellular exchange of nutrients and waste products.
The endogenous production of phosphatidylserine is a very difficult and energy consuming process. It requires the combination of L-serine, glycerphosphate, and two fatty acids, and the aid of methyl donors such as B-12. folic acid, S-adensylmethionine with essential fatty acids. Its arduous chemical synthesis that depends upon commonly deficient nutrients may explain why its e×ogenous intake has shown such great promise.
Perhaps the most clinically significant impact of PS is its ability to lower cortisol. An overactive hypothalamus-pituitary-adrenal a×is that induces hypercortisolemia has many adverse impacts on healthy metabolism. Elevated cortisol has been shown to induce insulin insensitivity, decrease TSH and T3 production. increase inactive reverse T3, decrease phase ll glucoronidation and sulfation, sup- press pituitary function, increase the potential for gastric and duodenal ulcers, Iower inlestinal secretary IgA delay intestinal mucosal cell generation, suppress immunity, decrease bone density, induce depression," encourage obesity, and increase the risk for cardiovascular and neurodegenerative disorders.
Therefore, the use of PS shows great promise in the management of disorders induced by the elevations of cortisol from chronic stress syndromes. Up until now, the use of PS was limited in clinical practice becauso very high doses of oral PS (up to 800 mg a day) are required to blunt the physiological stress response. This therapeutic dose of PS is very expensive and requires 8 or more capsules of intake per day which makes it difficult for patient compliance. Many of the best responses of PS in clinical studies also used intravenous forms of delivery. This appeared to be the best form of delivery because it bypassed the gastrointestinal tract and was able to be delivered directly into the blood stream.
The new innovative form of PS delivery in a cream has now allowed clini cians to use ther equired amounts of PS tomodulate the stress response. The PS cream allows hundreds of milligrams of PS to enter directly into the blood stream by bypassing the gastrointestinal tract. Transdormal delivery utilizes lipid spheres, known as liposomes, to transport PS through the skin and into the blood. Once there, the liposome shell around the PS substance degrades and makes PS available for active response in the blood stream.