Suggested Use

2 softgels up to three times daily - 2 to 6 softgels daily with food

Special Info

60 Softgel Bottle; 120 Softgel Bottle

Nutrition Info

EPA-DHA Extra Strength® Enteric-Coated

Concentrated Essential Fatty Acids 300 mg EPA / 200 mg DHA per Softgel

No Aftertaste!

EPA-DHA Extra Strength provides a higher concentration of the same cold water fish oil contained in EPA-DHA Complex®. It features high levels of the omega-3 essential fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA).

Features an odor-reduced, enteric-coated softgel decreases the potential for repeating and may improve patient compliance.

ANTI-INFLAMMATORY Support: EPA-DHA Extra Strength Lemon or Enteric Coated - 3, three times a day
UltraInflamX - 2 scoops, one to four times per day
Kaprex - leaoding dose of 8, then: Acute - 2 every 2 hours, Chronic - 2, two times a day
Inflavanoid Intensive Care - 2, three times a day
Alapars - 1, three times a day

EPA-DHA Extra Strength® - Purity-Certified Essential Fatty Acids From Cold-Water Fish

Why Choose EPA-DHA Extra Strength® From Metagenics?

• Our fish oil is obtained from the only raw material supplier granted a Certificate of Suitability by the European Directorate for the Quality of Medicines. This certificate means the oil meets or exceeds the European Pharmacopoeia standards for omega-3 triglycerides. The European Pharmacopoeia—like the United States Pharmacopeia (USP)—publishes the "gold-standard" criteria for identity, quality, purity, and strength of material for clinical use. The USP does not provide any published criteria for fish oils.

• Purity-Certified: True to Metagenics’ long history of self-imposed quality standards, our fish oil is purity-certified for your peace of mind.

• Safety: Using only oil with certified purity means you don’t have to worry about heavy metals (e.g. mercury), pesticides (DDTs, PCBs, etc.), and other contaminants.

• Stability: Employing state-of-the-art processing technology, utilizing purity-certified oils in triglyceride form, and adding vitamin E all support optimal stability and freshness of the oils—as evidenced by the peroxide and anisidine values of every batch.

• Bioavailability: Provided in triglyceride form rather than ethyl ester form for optimal absorption.

• Pleasant-smelling, enteric-coated: For individuals who are sensitive to even the slightest "fish smell" and those who are susceptible to fish-oil aftertaste (repeating).

How You Will Benefit From EPA-DHA Extra Strength®:

• Promotes the healthy structure, composition, and function of cell membranes.

• Supports a healthy, balanced production of eicosanoids.

• May support T-helper cell subset (Th1, Th2) balance.

• Supports healthy skin and healthy cardiovascular, nervous, and immune system function.

• Supplies high levels of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), thereby eliminating the biological burden of enzymatic conversion from alpha-linolenic acid.

Pleasant-Smelling and Enteric-Coated -
EPA-DHA Extra Strength is now provided in an odorreduced form with an advanced, pH-sensitive enteric coating that prevents premature breakdown of the softgel in the stomach, but allows for optimal dissolution in the intestine. These improvements were made to support compliance in patients who have a sensitivity to even the slightest "fish odor"and patients who are prone to experience a fish oil aftertaste (repeating) due to their unique biology.

Exceptional Quality and Purity -
For maximum value and benefit, EPA-DHA Extra Strength is held to strict quality standards from sourcing of the raw material to final processing. A proprietary process employing stateof-the-art technology removes polar, colored, and odorous impurities without chemically altering the nature of the oils. These advanced procedures also help protect the oil from oxidation, resulting in a more stable final product. Furthermore, for enhanced health and safety, EPA-DHA Extra Strength is "cholesterol-free"and assayed for peroxides, anisidine, and environmental contaminants, such as mercury and pesticides.

EPA-DHA Extra Strength supplies EPA and DHA in triglyceride form for optimal absorption. Many essential fatty acid (EFA) supplements on the market are provided in the form of ethyl esters or free fatty acids.

Ethyl ester formulas represent an intermediate stage in the manufacture of high quality EFA supplements; they are common because they require fewer processing steps and therefore cost less to manufacture.

In addition, research suggests that glycerides are better absorbed than ethyl esters and more stable than free fatty acid forms. Higher stability means reduced potential for repeating. In addition, vitamin E—in the form of d-alpha tocopherol and mixed tocopherols—is added to help guard against oxidation and maintain the freshness of the formula itself.

Current scientific literature provides evidence that fatty acids may be some of the most essential nutrients in the human diet. Because of their influence on cell membrane structure, composition, and function as well as their role in eicosanoid synthesis, EPA and DHA exercise a powerful influence on overall health.1-7

Membrane Structure and Function -

Cell membrane structural phospholipids contain high concentrations of polyunsaturated fatty acids (PUFAs), such as EPA, DHA, and arachidonic acid (AA). Cell membrane fatty acid composition is largely reflective of dietary intake and can affect physical properties of the phospholipid, including fluidity of the membrane, receptor function, cell signaling mechanisms, membrane-bound enzymes, and regulation of eicosanoid synthesis and gene expression. For instance, research indicates that inadequate membrane DHA can alter receptor function, either exaggerating or diminishing the effects of hormones such as estrogen and insulin.1,2

Balanced Eicosanoid Production -

Some of the most potent effects of EPA and DHA are related to their enzymatic conversion into eicosanoids. Eicosanoids are short-lived, locally active, hormone-like substances present in tissues throughout the body that function as mediators of a variety of physiological responses, including immune activity. Omega- 3 fatty acids as a whole, and specifically EPA and DHA, are typically underconsumed in the West; therefore, supplementation is essential for many. On the other hand, Westerners typically consume diets too high in AA (largely from meats) and other omega-6 fatty acids (primarily from soy, corn, safflower, and sunflower oils). This imbalance may result in a greater biosynthesis of AA-derived eicosanoids, which can negatively impact tissues throughout the body including those of the joints, nervous system, and cardiovascular system.1,3

Th1/Th2 Balance -

Research also suggests that omega-3 fatty acids may help balance T-helper cell subset (Th1,Th2) responses. Imbalances in Th1/Th2 responses are associated with the development of specific, undesirable immune activity and the perpetuation of AA-derived eicosanoid production.4

Healthy Skin -

The skin epidermis has a highly active metabolism of PUFAs. A deficiency of omega-3 fatty acids is associated with a higher local production of eicosanoids that can promote damage, resulting in undesirable changes in skin texture and appearance. Supplementation with EPA and DHA may result in less epidermal reactivity, which may improve skin appearance.

Cardiovascular Health -
Fish oils beneficially impact multiple parameters of cardiovascular health, including serum fibrinogen, platelet aggregation, and blood viscosity. They also support healthy blood pressure, healthy levels of triglycerides and high-density lipoproteins, and limit the production of damaging eicosanoids that affect arterial health.1,2

Central Nervous System -
Omega-3 fatty acids are vital structural components of brain and nervous tissue. The brain is particularly rich in PUFAs, such as AA, EPA, and DHA, and changes in the tissue membrane composition are reflective of intake. Research suggests that substitution of EPA/DHA for AA in brain phospholipids may result in less damaging cyclooxygenasedependent cerebrovascular reactivity. Furthermore, adequate levels of physiological DHA are required for normal brain function and decreases in brain DHA content are associated with age-related cognitive decline. The literature also provides evidence that adequate physiological levels of AA and DHA are crucial during pregnancy for normal fetal development and during breastfeeding for continued central nervous system development.1,6

Retinal Health -
DHA is a major component of the retina and is preferentially taken up and retained by phospholipid membranes of photo-receptors therein. In addition, DHA is an important determinant of visual pigment content and kinetics in the developing photoreceptor cell. Scientific literature focuses on proper DHA nutrition for retinal health in the preterm and breastfeeding infant.7

References:
1. Horrocks LA, Yeo YK. Health benefits of docosahexaenoic acid (DHA). Pharmacol Res 1999; 40(3):211-25.
2. Ziegler EE, Filer LJ, eds. Present Knowledge in Nutrition. Washington D.C.: ILSI; 1996.
3. Simopoulos AP, Human requirement for N-3 polyunsaturated fatty acids. Poult Sci 2000; 79(7):961-70.
4. Kankaanpaa P, Sutas Y, Salminen S, et al. Dietary fatty acids and allergy. Ann Med 1999; 31(4):282-87.
5. Ziboh VA. The significance of polyunsaturated fatty acids in cutaneous biology. Lipids 1996; Suppl 31:S249-53.
6. Heird WC, The role of polyunsaturated fatty acids in term and preterm infants and breastfeeding mothers. Pediatr Clin North Am 2001; 48(1):173-88.
7. Bazan NG, Rodriquez de Turco EB. Review: pharmacological manipulation of docosahexaenoicphospholipid biosynthesis in photoreceptor cells: implications in retinal degeneration. J Ocul Pharmacol 1994; 10(3):591-604.

These statements have not been evaluated by the Food and Drug Administration.

This product is not intended to diagnose, treat, cure, or prevent any disease.

©2002 Metagenics, Inc., MET678 12/02

Description

EPA-DHA Extra Strength® Enteric-Coated

Concentrated Essential Fatty Acids 300 mg EPA / 200 mg DHA per Softgel

No Aftertaste!

EPA-DHA Extra Strength provides a higher concentration of the same cold water fish oil contained in EPA-DHA Complex®. It features high levels of the omega-3 essential fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA).

Features an odor-reduced, enteric-coated softgel decreases the potential for repeating and may improve patient compliance.

ANTI-INFLAMMATORY Support: EPA-DHA Extra Strength Lemon or Enteric Coated - 3, three times a day
UltraInflamX - 2 scoops, one to four times per day
Kaprex - leaoding dose of 8, then: Acute - 2 every 2 hours, Chronic - 2, two times a day
Inflavanoid Intensive Care - 2, three times a day
Alapars - 1, three times a day

EPA-DHA Extra Strength® - Purity-Certified Essential Fatty Acids From Cold-Water Fish

Why Choose EPA-DHA Extra Strength® From Metagenics?

• Our fish oil is obtained from the only raw material supplier granted a Certificate of Suitability by the European Directorate for the Quality of Medicines. This certificate means the oil meets or exceeds the European Pharmacopoeia standards for omega-3 triglycerides. The European Pharmacopoeia—like the United States Pharmacopeia (USP)—publishes the "gold-standard" criteria for identity, quality, purity, and strength of material for clinical use. The USP does not provide any published criteria for fish oils.

• Purity-Certified: True to Metagenics’ long history of self-imposed quality standards, our fish oil is purity-certified for your peace of mind.

• Safety: Using only oil with certified purity means you don’t have to worry about heavy metals (e.g. mercury), pesticides (DDTs, PCBs, etc.), and other contaminants.

• Stability: Employing state-of-the-art processing technology, utilizing purity-certified oils in triglyceride form, and adding vitamin E all support optimal stability and freshness of the oils—as evidenced by the peroxide and anisidine values of every batch.

• Bioavailability: Provided in triglyceride form rather than ethyl ester form for optimal absorption.

• Pleasant-smelling, enteric-coated: For individuals who are sensitive to even the slightest "fish smell" and those who are susceptible to fish-oil aftertaste (repeating).

How You Will Benefit From EPA-DHA Extra Strength®:

• Promotes the healthy structure, composition, and function of cell membranes.

• Supports a healthy, balanced production of eicosanoids.

• May support T-helper cell subset (Th1, Th2) balance.

• Supports healthy skin and healthy cardiovascular, nervous, and immune system function.

• Supplies high levels of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), thereby eliminating the biological burden of enzymatic conversion from alpha-linolenic acid.

Pleasant-Smelling and Enteric-Coated -

EPA-DHA Extra Strength is now provided in an odorreduced form with an advanced, pH-sensitive enteric coating that prevents premature breakdown of the softgel in the stomach, but allows for optimal dissolution in the intestine. These improvements were made to support compliance in patients who have a sensitivity to even the slightest "fish odor"and patients who are prone to experience a fish oil aftertaste (repeating) due to their unique biology.

Exceptional Quality and Purity -

For maximum value and benefit, EPA-DHA Extra Strength is held to strict quality standards from sourcing of the raw material to final processing. A proprietary process employing stateof-the-art technology removes polar, colored, and odorous impurities without chemically altering the nature of the oils. These advanced procedures also help protect the oil from oxidation, resulting in a more stable final product. Furthermore, for enhanced health and safety, EPA-DHA Extra Strength is "cholesterol-free"and assayed for peroxides, anisidine, and environmental contaminants, such as mercury and pesticides.

EPA-DHA Extra Strength supplies EPA and DHA in triglyceride form for optimal absorption. Many essential fatty acid (EFA) supplements on the market are provided in the form of ethyl esters or free fatty acids.

Ethyl ester formulas represent an intermediate stage in the manufacture of high quality EFA supplements; they are common because they require fewer processing steps and therefore cost less to manufacture.

In addition, research suggests that glycerides are better absorbed than ethyl esters and more stable than free fatty acid forms. Higher stability means reduced potential for repeating. In addition, vitamin E—in the form of d-alpha tocopherol and mixed tocopherols—is added to help guard against oxidation and maintain the freshness of the formula itself.

Current scientific literature provides evidence that fatty acids may be some of the most essential nutrients in the human diet. Because of their influence on cell membrane structure, composition, and function as well as their role in eicosanoid synthesis, EPA and DHA exercise a powerful influence on overall health.1-7

Membrane Structure and Function -

Cell membrane structural phospholipids contain high concentrations of polyunsaturated fatty acids (PUFAs), such as EPA, DHA, and arachidonic acid (AA). Cell membrane fatty acid composition is largely reflective of dietary intake and can affect physical properties of the phospholipid, including fluidity of the membrane, receptor function, cell signaling mechanisms, membrane-bound enzymes, and regulation of eicosanoid synthesis and gene expression. For instance, research indicates that inadequate membrane DHA can alter receptor function, either exaggerating or diminishing the effects of hormones such as estrogen and insulin.1,2

Balanced Eicosanoid Production -

Some of the most potent effects of EPA and DHA are related to their enzymatic conversion into eicosanoids. Eicosanoids are short-lived, locally active, hormone-like substances present in tissues throughout the body that function as mediators of a variety of physiological responses, including immune activity. Omega- 3 fatty acids as a whole, and specifically EPA and DHA, are typically underconsumed in the West; therefore, supplementation is essential for many. On the other hand, Westerners typically consume diets too high in AA (largely from meats) and other omega-6 fatty acids (primarily from soy, corn, safflower, and sunflower oils). This imbalance may result in a greater biosynthesis of AA-derived eicosanoids, which can negatively impact tissues throughout the body including those of the joints, nervous system, and cardiovascular system.1,3

Th1/Th2 Balance -

Research also suggests that omega-3 fatty acids may help balance T-helper cell subset (Th1,Th2) responses. Imbalances in Th1/Th2 responses are associated with the development of specific, undesirable immune activity and the perpetuation of AA-derived eicosanoid production.4

Healthy Skin -

The skin epidermis has a highly active metabolism of PUFAs. A deficiency of omega-3 fatty acids is associated with a higher local production of eicosanoids that can promote damage, resulting in undesirable changes in skin texture and appearance. Supplementation with EPA and DHA may result in less epidermal reactivity, which may improve skin appearance.

Cardiovascular Health -

Fish oils beneficially impact multiple parameters of cardiovascular health, including serum fibrinogen, platelet aggregation, and blood viscosity. They also support healthy blood pressure, healthy levels of triglycerides and high-density lipoproteins, and limit the production of damaging eicosanoids that affect arterial health.1,2

Central Nervous System -

Omega-3 fatty acids are vital structural components of brain and nervous tissue. The brain is particularly rich in PUFAs, such as AA, EPA, and DHA, and changes in the tissue membrane composition are reflective of intake. Research suggests that substitution of EPA/DHA for AA in brain phospholipids may result in less damaging cyclooxygenasedependent cerebrovascular reactivity. Furthermore, adequate levels of physiological DHA are required for normal brain function and decreases in brain DHA content are associated with age-related cognitive decline. The literature also provides evidence that adequate physiological levels of AA and DHA are crucial during pregnancy for normal fetal development and during breastfeeding for continued central nervous system development.1,6

Retinal Health -

DHA is a major component of the retina and is preferentially taken up and retained by phospholipid membranes of photo-receptors therein. In addition, DHA is an important determinant of visual pigment content and kinetics in the developing photoreceptor cell. Scientific literature focuses on proper DHA nutrition for retinal health in the preterm and breastfeeding infant.7

References:
1. Horrocks LA, Yeo YK. Health benefits of docosahexaenoic acid (DHA). Pharmacol Res 1999; 40(3):211-25.
2. Ziegler EE, Filer LJ, eds. Present Knowledge in Nutrition. Washington D.C.: ILSI; 1996.
3. Simopoulos AP, Human requirement for N-3 polyunsaturated fatty acids. Poult Sci 2000; 79(7):961-70.
4. Kankaanpaa P, Sutas Y, Salminen S, et al. Dietary fatty acids and allergy. Ann Med 1999; 31(4):282-87.
5. Ziboh VA. The significance of polyunsaturated fatty acids in cutaneous biology. Lipids 1996; Suppl 31:S249-53.
6. Heird WC, The role of polyunsaturated fatty acids in term and preterm infants and breastfeeding mothers. Pediatr Clin North Am 2001; 48(1):173-88.
7. Bazan NG, Rodriquez de Turco EB. Review: pharmacological manipulation of docosahexaenoicphospholipid biosynthesis in photoreceptor cells: implications in retinal degeneration. J Ocul Pharmacol 1994; 10(3):591-604.

These statements have not been evaluated by the Food and Drug Administration.

This product is not intended to diagnose, treat, cure, or prevent any disease.

©2002 Metagenics, Inc., MET678 12/02