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This product from the larch tree contains long densely branched high molecular weight polysaccharides similar to those in Echinacea and therapeutic mushrooms. It is immune stimulating and extremely useful in acute viral infections.
Although outcome studies on the clinical applications of this novel polysaccharide have not been conducted to date, its physiological properties suggest a broad range of potential therapeutic applications. As a dietary fiber supplement, larch arabinogalactan has several beneficial properties, including the ability to promote the growth of friendly bacteria, increase the production of SCFA's(Short Chain Fatty Acids) and decrease ammonia generation. Since most diets are deficient in dietary fiber, the ability to simultaneously enhance immune activity, while boosting fiber intake, suggests a dual advantage of this unique polysaccharide as a dietary fiber.
Here is an animation that illustrates the basic cell-cell interactions that lead to antibody production.
As a biological response modifier, larch arabinogalactan also appears to offer substantial promise. The currently documented effects on NK (Natural Killer (immunology) cytotoxicity, along with its effects on the function of the mononuclear portion of the immune system, suggest an array of clinical uses both in preventive medicine, due to its ability to build a more responsive immune system, and in clinical medicine, as a therapeutic agent in conditions associated with lowered immune function or decreased NK activity.
Perhaps the greatest potential of this polysaccharide is as a biological response modifier to support conventional cancer treatments. The combination of its immune-enhancing properties along with its anti-metastatic activity fulfills two therapeutically desirable goals. While modified citrus pectin has received attention in both conventional and alternative medical journals for its anti-metastatic activity, larch arabinogalactan works in essentially the same manner, that is, by inhibiting the attachment of metastatic cells to liver parenchyma via competitive binding to liver hepatic galactose receptors; larch arabinogalactan, however, offers the additional advantage of enhancing immune function.
Larch arabinogalactan's NK-modulating activity appears to be similar in nature to the mechanism of action of Viscum album. Based on available evidence of a lack of synergism, no advantage appears to exist in combining these two substances. The use of larch arabinogalactan offers anti-metastatic activity, as well as its positive effects on gut micro-flora and SCFAs, the latter two benefits not found with V. album.
NK cells do not kill indiscriminately. They look for a banner flown by normal cells. If the NK cell sees this banner, it receives a signal to spare that cell. This signal overrides the NK cell's urge to kill. If this banner is absent on the target cell the NK cell proceeds with its attack. It attaches to the target and releases a lethal burst of chemicals that penetrate the cell wall. Fluids begin to leak in and out and eventually the cell explodes.
In addition to their role in the control of infections, NK cells help in the regulation of other aspects of the immune system which effects our overall health. Immunotherapy to help increase NK cell acuity is becoming available and will become more widely used as knowledge of the immune system increases.