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If Progesterone cream has been used for a year or more, consider a Saliva test to measure Free Progesterone. Levels can be 100's of times over normal and Metacrine DX along with Methyl SP and Bile Min can be used to support the liver clearing the stored hormones until they are normal, repeat saliva testing will be needed and will show the removal of these hormones , which although stored may cause the receptor sites where hormones bind to become much less active.
These stored hormones may also cause an increased conversion of estrogen into testosterone, as well as other hormone imbalances.