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Simply put PS helps brain communication and exchanging nutrition for waste.
PS is an endogenously ( inside the body) produced phospholipid that is embedded in cell membranes and is the major phospholipids in the brain. Its general functions include supporting cellular chemical signal transmissions, activating cell surface receptors and cellular exchange of nutrients and waste products.
Perhaps the most clinically significant impact of PS is its ability to lower cortisol. An overactive hypothalamus-pituitary-adrenal axis that induces (creates) hypercortisolemia (High Cortisol) has many adverse impacts on healthy metabolism.
Elevated cortisol has been shown to induce insulin insensitivity (pre-diabetic), decrease TSH (Thyroid Stimulating Hormone) and T3 (Thyroid Hormone) production. increase inactive reverse T3 (Inactive Thyroid Hormone) ,decrease phase ll glucoronidation and sulfation (Liver Detoxification), suppress pituitary function, increase the potential for gastric and duodenal ulcers, Iower intestinal secretary IgA, delay intestinal mucosal cell generation (Repair the Gut), suppress immunity, decrease bone density, induce depression," as well as encourage obesity and increase the risk for cardiovascular and neurodegenerative disorders. Supporting the brain to be calmed down and repaired with the help of PS is important.
Therefore, the use of PS shows great promise in the management of disorders induced by the elevations of cortisol from chronic stress syndromes. Up until now, the use of PS was limited in clinical practice becauso very high doses of oral PS (up to 800 mg a day) are required to blunt the physiological stress response. This therapeutic dose of PS is very expensive and requires 8 or more capsules of intake per day which makes it difficult for patient compliance. Many of the best responses of PS in clinical studies also used intravenous forms of delivery. This appeared to be the best form of delivery because it bypassed the gastrointestinal tract and was able to be delivered directly into the blood stream.
The new innovative form of PS delivery in a cream has now allowed clinicians to use the required amounts of PS to modulate the stress response. The PS cream allows hundreds of milligrams of PS to enter directly into the blood stream by bypassing the gastrointestinal tract. Transdermal delivery utilizes lipid spheres, known as liposomes, to transport PS through the skin and into the blood. Once there, the liposome shell around the PS substance degrades and makes PS available for active response in the blood stream.